The paper shows the high therapeutical efficiency of combined He-Ne laser therapy in patients with coronary heart disease. Its effect on the thromboxane-prostacyclin system is one of the mechanisms of laser impact. The combined He-Ne laser therapy promotes normalization of the level of thromboxane B2 and its ratio to the metabolite prostacyclin.
Angina Pectoris/blood , Laser Therapy , Prostaglandins/metabolism , Prostaglandins/radiation effects , Adult , Aged , Angina Pectoris/metabolism , Epoprostenol/blood , Epoprostenol/metabolism , Epoprostenol/radiation effects , Humans , Middle Aged , Prostaglandins/blood , Thromboxane B2/blood , Thromboxane B2/metabolism , Thromboxane B2/radiation effects , Thromboxanes/blood , Thromboxanes/metabolism , Thromboxanes/radiation effects , Time Factors
There was a relationship of the degree of imbalance between thromboxane and prostacyclin, prostaglandins (PG) F2 alpha and E1 in patients with coronary heart disease concurrent with stable angina pectoris. A significant increase in the levels of thromboxane and PGF2 alpha was found with relative prostacyclin and PGE1 deficiency during graded exercise at the moment of transient myocardial ischemia; the imbalance significantly increased as exercise tolerance decreased. Transient myocardial ischemia induced by transesophageal left atrial pacing revealed unidirectional changes in plasma PG, as did exercise.
Blood Platelets/physiology , Blood Vessels/physiopathology , Hemostasis , Myocardial Ischemia/blood , Physical Exertion/physiology , Rest/physiology , Adult , Angina Pectoris/blood , Angina Pectoris/physiopathology , Exercise Test , Exercise Tolerance/physiology , Humans , Male , Middle Aged , Myocardial Ischemia/physiopathology , Prostaglandins/blood